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Migraine is a highly prevalent primary headache, which is characterized by intermittent headache attacks of pulsatile quality, moderate to severe intensity and aggravation by physical efforts. The duration varies from 4 to 72 hours if untreated and nausea; vomiting, photophobia, phonophobia and osmophobia may accompany the headache itself. The frequency of attacks is variable and pathophysiological mechanisms, which may include central serotonergic, noradrenergic and dopaminergic dysfunctions as well as cortical hyperexcitability and abnormal PAG deposition of non-heme iron is speculated. In addition, peripheral and central sensitization may be observed and during the headache attacks there is inflammation and dilatation of meningeal blood vessels. The treatment includes patient's education, prophylaxis with various classes of medications and efficient use of acute therapies. The combination of different drugs is common among professionals seeking for better outcome parameters. Usually there is sensible improvement in headache frequency and quality of life with efficient treatments.

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