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Summary

The physicochemical stability of calcium folinate (leucovorin calcium), fluorouracil and methotrexate formulations (Fauldleuco, Fauldfluor and Fauldmetro, respectively), kept in their primary package container, was evaluated after perforating the vials for solution appearance, pH, drug identification, assay, particulate matter and also for related compounds. Results showed no physicochemical significant alterations after perforating the vials when fluorouracil and methotrexate formulations were stored at room temperature (20-25oC) for 7 days and when calcium folinate formulations were kept in the refrigerator (2-8oC) for 7 days, all conditions protected from light.



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